Potassium Channel

KcsA

Potassium Channel

Related Products

Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Potassium Channel Related Products (751)
Antibodies (5)

By Effects:	Controls (5) Inhibitors (483) Agonists (10) Antagonists (30) Activators (147) Modulators (25) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-B1430R

Butamben (Standard)	Inhibitor
Butamben (Standard) is the analytical standard of Butamben. This product is intended for research and analytical applications. Butamben (Butyl 4-aminobenzoate) results in long-lasting relief from pain, without impairing motor function or other sensory functions.

HY-147256

Cavutilide	Inhibitor
Cavutilide (Niferidil) is a class III antiarrhythmic agent that inhibits hERG K⁺ channel. Cavutilide has the potential for the study of persistent atrial fibrillation.

HY-B1751E

Quinidine polygalacturonate	Inhibitor
Quinidine polygalacturonate is an antiarrhythmic agent. Quinidine polygalacturonate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine polygalacturonate is also a K⁺ channel blocker with an IC₅₀ of 19.9 μM, and can induce apoptosis. Quinidine polygalacturonate can be used for malaria research.

HY-108400

SCH-23390 maleate	Inhibitor
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective dopamine D₁-like receptor antagonist with K_is of 0.2 nM and 0.3 nM for the D₁ and D₅ receptor, respectively. SCH-23390 maleate is a potent and high efficacy human 5-HT_2C receptor agonist with a K_i of 9.3 nM. SCH-23390 maleate also binds with high affinity to the 5-HT₂ and 5-HT_1C receptors. SCH-23390 maleate inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC₅₀ of 268 nM.

HY-126704

Tedisamil
Tedisamil (KC-8857) is an antiarrhythmic compound with important biological activities. Tedisamil exhibits a significant slowing effect on heart rate, which is achieved by inhibiting the transient outward potassium current (I(to)) in the atrium. Tedisamil inhibits multiple potassium currents, including IK, K(ATP), and PKA-activated chloride channels, thereby prolonging the cardiac action potential and QT interval, and increasing cardiac reentry. Tedisamil has antiarrhythmic effects on ventricular arrhythmias and atrial flutter in animal models.

HY-14187S1

Amiodarone-d₅ hydrochloride	Inhibitor
Amiodarone-d₅ hydrochloride is deuterated labeled Amiodarone (HY-14187). Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC₅₀ of 19.1 μM.

HY-108578

RuBi-4AP	Inhibitor
RuBi-4AP, a derivative of 4-aminopyridine (4AP; HY-B0604), is a caged K_v channel blocker. RuBi-4AP contains a photolabile protecting group, allowing its effect to be controlled precisely in both space and time with light. RuBi-4AP can be used for the research of neuronal excitability, synaptic transmission, and signal propagation.

HY-B0267AR

Oxybutynin chloride (Standard)	Inhibitor
Oxybutynin (chloride) (Standard) is the analytical standard of Oxybutynin (chloride). This product is intended for research and analytical applications. Oxybutynin chloride is an oral active and competitive mAChR antagonist with K_is of 14.3 and 5.55 nM for specific [³H]NMS binding in the mouse bladder and cerebral cortex, respectively. Oxybutynin chloride inhibits vascular Kv channels in a manner independent of anticholinergic effect, with an IC₅₀ value of 11.51 μM. Oxybutynin chloride reduces muscle spasm in the bladder and urinary tract, can be used in study of overactive bladder syndrome (OAB). Oxybutynin (chloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0563BS

Ropivacaine-d₇ hydrochloride	Inhibitor
Ropivacaine-d₇ hydrochloride is a deuterium labeled Ropivacaine (hydrochloride) (HY-B0563B). Ropivacaine hydrochloride is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K_2P (two-pore domain potassium channel) TREK-1 with an IC₅₀ of 402.7 μM in COS-7 cell's membrane. Ropivacaine is widely used for neuropathic pain management in vivo.

HY-P5871

Jingzhaotoxin-XII	Inhibitor
Jingzhaotoxin-XII (JzTx-XII) is a specific Kv4.1 channel inhibitor with an IC₅₀ of 0.363 μM. Jingzhaotoxin-XII interacts with the channels by modifying the gating behavior.

HY-17504D

(3S,5R)-Rosuvastatin	Inhibitor
(3S,5R)-Rosuvastatin is the (3S,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC₅₀ of 11 nM. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC₅₀ of 195 nM. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.

HY-110076

VU590 dihydrochloride	Inhibitor
VU590 dihydrochloride is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC₅₀ of 290 nM. VU590 also inhibits Kir7.1, with an IC₅₀ of 8 μM. VU590 dihydrochloride is not a good probe of ROMK function in the kidney.

HY-P2786A

Phrixotoxin 2	Inhibitor
Phrixotoxin 2 is a highly selective KV_4.2 and KV_4.3-channels blocker.

HY-118683

KR-31378	Activator
KR-31378 is a neuroprotectant with dose-dependent pharmacokinetic properties and relevant activity in rats. After intravenous and oral administration of KR-31378 in rats, its pharmacokinetic parameters showed dose-dependent changes, such as decreased clearance with increasing doses, good oral absorption, and comparable AUCs for intravenous and oral administration at different doses.

HY-P5165

Maurotoxin	Inhibitor
Maurotoxin is a 34-residue and four disulde-bridged toxin that can be isolated from the chactoid scorpion (Scorpio maurus). Maurotoxin inhibits the Shaker potassium channels (ShB) K⁺ current with an IC₅₀ of 2 nM.

HY-P1280A

Margatoxin TFA	Inhibitor
Margatoxin TFA, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (K_d=11.7 pM). Margatoxin TFA inhibits the Kv1.2 (K_d=6.4 pM) and Kv1.1 (K_d=4.2 nM). Margatoxin TFA, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research.

HY-B0405AR

Bupivacaine (hydrochloride) (Standard)	Inhibitor	99.99%
Bupivacaine (hydrochloride) (Standard) is the analytical standard of Bupivacaine (hydrochloride). This product is intended for research and analytical applications. Bupivacaine hydrochloride is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC₅₀ of 69.5 μM. Bupivacaine hydrochloride can be used for the research of chronic pain.

HY-106912A

L-706000 free base	Inhibitor
L-706000 (MK 499) free base is a potent hERG channel blocker with an IC₅₀ of 32 nM. L-706000 free base is a class III antiarrhythmic agent that can be used for the study of malignant ventricular tachyarrhythmias.

HY-P1426

AmmTX3	Inhibitor
AmmTX3 is a peptide toxin that can be isolated from the venom of the scorpion Androctonus mauretanicus. AmmTX3 is specific blocker of K_v4 channel. AmmTX3 inhibits the A-type K⁺ current (K_i: 131 nM).

HY-P5887

Tertiapin-RQ	Inhibitor
Tertiapin-RQ is an inward rectifier K⁺ channel blocker peptide with antidepressive effect.

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Potassium Channel

Potassium Channel

Potassium Channel Related Products (751)

Antibodies (5)

Potassium Channel Related Products (751):